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#:~:text=PHILADELPHA—Inflammation in the blood,of Pennsylvania published in JCI see more

New Biomarker May Predict Which Pancreatic Cancer Patients Respond to CD40 Immunotherapy - Penn Medicine

Inflammation in the blood could serve as a new biomarker to help identify patients with advanced pancreatic cancer who won't respond to the immune-stimulating drugs known as CD40 agonists, suggests ..... see more

Source : https://www.pennmedicine.org/news/news-releases/2021/february/new-biomarker-may-predict-which-pancreatic-cancer-patients-respond-to-cd40-immunotherapy

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IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy

Background Oncolytic viruses (OVs) have shown promise in containing cancer progression in both animal models and clinical trials. How to further improve the efficacy of OVs are intensively explored. Arming ..... see more

Source : https://jitc.bmj.com/content/9/1/e001647

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Pan-Cancer Molecular Characterization of m6A Regulators and Immunogenomic Perspective on the Tumor Microenvironment

Dramatic progresses have been made in the field of cancer immunity and immunotherapy during the preceding 15 years. The clinical impact associated with the tumor immune infiltrate, the impressive clinical ..... see more

Source : https://www.frontiersin.org/journals/oncology/sections/cancer-immunity-and-immunotherapy

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Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis

ABSTRACT Multiple Myeloma (MM) is a malignant disorder of plasma cells which, despite significant advances in treatment, remains incurable. Daratumumab, the first CD38 directed monoclonal antibody, has shown promising activity ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1859263

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Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma

ABSTRACT Immune checkpoint inhibitors (ICIs) offer significant clinical benefits to a subset of cancer patients via the induction of a systemic T cell-mediated anti-cancer immune response. Thus, the dynamic characterization ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1862948

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Expression of NKG2D ligands is downregulated by beta-catenin signaling and associates with HCC aggressiveness - PubMed

The NKG2D system is a potent immunosurveillance mechanism in cancer. The expression of NKG2D ligands has been little investigated in HCC. We show here, in a large cohort of HCC ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33484773/

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Approved drug could make radiation therapy more effective for head, neck cancer: study

Head and neck cancer is the sixth most common cancer worldwide, and while effective treatments exist, sadly, the cancer often returns. Researchers at the University of Cincinnati have tested a ..... see more

Source : https://medicalxpress.com/news/2021-01-drug-therapy-effective-neck-cancer.html

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Prognostic Implications of Pan-Cancer CMTM6 Expression and Its Relationship with the Immune Microenvironment

CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) reportedly stabilizes programmed death-ligand 1 (PD-L1) and enhances the efficacy of immunotherapy. However, correlations between CMTM6 expression and the immune microenvironment and its prognostic ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fonc.2020.585961/full

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#:~:text=In this study, published today,common type of pancreatic cancer. see more

Novel target identified that could improve safety of therapy for pancreatic cancer

Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer. Using this protein as a target, ..... see more

Source : https://www.eurekalert.org/pub_releases/2021-01/qmuo-nti012221.php

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Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations

Pancreatic cancer is an inflammatory malignancy, and tumor-associated macrophages (TAMs) are the predominant inflammatory cells in tumor tissue. TAMs have complicated interactions with pancreatic cancer cells, however, the details and ..... see more

Source : https://link.springer.com/article/10.1007/s00262-020-02816-0