Skip to main content
micro-community-banner
 
  • Saved

made a Post

Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial

Background The extent to which response and survival benefits with immunotherapy-based regimens persist informs optimal first-line treatment options. We provide long-term follow-up in patients with advanced renal cell carcinoma (aRCC) ..... see more

Source : https://jitc.bmj.com/content/8/2/e000891

  • Saved

made a Post

Somatostatin Receptors in Merkel-Cell Carcinoma: A Therapeutic Opportunity Using Somatostatin Analog Alone or in Association With Checkpoint Inhibitors Immunotherapy. A Case Report

Background: Merkel-cell carcinoma (MCC) is a rare, highly aggressive skin cancer typically involving elderly people. Surgery is usually the first treatment for primary tumor. In adjuvant setting, radiotherapy is effective ..... see more

Source : https://doi.org/10.3389/fonc.2020.01073

  • Saved

made a Post

Predicting response to immunotherapy in advanced non-small-cell lung cancer using tumor mutational burden radiomic biomarker

Background Tumor mutational burden (TMB) is a significant predictor of immune checkpoint inhibitors (ICIs) efficacy. This study investigated the correlation between deep learning radiomic biomarker and TMB, including its predictive ..... see more

Source : https://jitc.bmj.com/content/8/2/e000550

  • Saved

made a Post

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

ABSTRACT ABSTRACT Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects. In order to minimize ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1785608

  • Saved

made a Post

Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma

ABSTRACT ABSTRACT Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not clearly determined. Moreover, ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1779990

  • Saved

made a Post

Peripheral Blood Biomarkers Associated With Outcome in Non-small Cell Lung Cancer Patients Treated With Nivolumab and Durvalumab Monotherapy

Background: Selecting patients who potentially benefit from immune checkpoint inhibitors (ICIs) is critical. Programmed death ligand-1 (PD-L1) protein immunohistochemical expression on cancer cells or immune cells and next-generation sequencing-based tumor ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fonc.2020.00913/full

  • Saved

made a Post

Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy

ABSTRACT The induction of tumor-targeted, cytotoxic T lymphocytes has been recognized as a key component to successful immunotherapy. DPX-based treatment was previously shown to effectively recruit activated CD8+ T cells ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1782574

  • Saved

made a Post

Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy

Tumor-treating fields (TTFields) are alternating electric fields in a specific frequency range (100-300 kHz) delivered to the human body through transducer arrays. In this study, we evaluated whether TTFields-mediated cell ..... see more

Source : https://link.springer.com/article/10.1007/s00262-020-02534-7

  • Saved

made a Post

A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice

ABSTRACT Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression in resident antigen-presenting cells. We report here that the rejection of CT26 tumors, mediated by local ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1771925

  • Saved

made a Post

Histopathological growth patterns correlate with the immunoscore in colorectal cancer liver metastasis patients after hepatectomy

Various scoring systems have been proposed to predict the postoperative prognosis of colorectal liver metastasis (CRLM), including the clinical risk score (CRS), the immunoscore and so on. Recently, histopathological growth ..... see more

Source : https://link.springer.com/article/10.1007/s00262-020-02632-6

  • Saved

made a Post

IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils

ABSTRACT In many types of cancer, presence of eosinophils in tumors correlate with an improved disease outcome. In line with this, activated eosinophils have been shown to reduce tumor growth ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1776059

  • Saved

made a Post

Impact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitors

ABSTRACT Immune checkpoint inhibitors (ICI) have become an important treatment option for non-small cell lung cancer (NSCLC). We aimed to evaluate the clinical impact of pseudoprogression (PsP) and treatment beyond ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1776058

  • Saved

made a Post

Pretreatment Neutrophil-to-Lymphocyte Ratio (NLR) May Predict the Outcomes of Advanced Non-small-cell Lung Cancer (NSCLC) Patients Treated With Immune Checkpoint Inhibitors (ICIs)

Background: Recent studies have demonstrated the predictive value of pretreatment neutrophil-to-lymphocyte ratio (NLR) in advanced cancers; however, the role of NLR in patients with advanced non-small-cell lung cancer (NSCLC) treated ..... see more

Source : https://doi.org/10.3389/fonc.2020.00654

  • Saved

made a Post

Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8 + T cells in gastric cancer

With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of ..... see more

Source : https://link.springer.com/article/10.1007/s00262-020-02550-7

  • Saved

View the Lecture On-Demand: Managing Oncology Patients During and Post-COVID-19

  • Saved

made a Post

Positive Status of Epstein-Barr Virus as a Biomarker for... : Journal of Immunotherapy

c features, the positive status of EBV is a potential biomarker. We prospectively recruited 9 patients who were diagnosed with stage-IV EBVaGC, and all of the patients were treated by ..... see more

Source : https://journals.lww.com/immunotherapy-journal/Fulltext/2020/05000/Positive_Status_of_Epstein_Barr_Virus_as_a.4.aspx?WT.mc_id=HPxADx20100319xMP

  • Saved

made a Post

BCMA-targeting Bispecific Antibody That Simultaneously... : Journal of Immunotherapy

tive malignancies including MM. MICA activates natural killer (NK) cells and costimulates T cells by interaction with its immunoreceptor NK cell receptor G2D (NKG2D). Nonetheless, during full-blown MM, tumor cells ..... see more

Source : https://journals.lww.com/immunotherapy-journal/Abstract/2020/07000/BCMA_targeting_Bispecific_Antibody_That.1.aspx

  • Saved

Commented on 's Post


65 Year-Old African American Female with Severe Fatigue, Cough, Nausea, and Back Pain


HOPI

65 y/o AAF presents to the office with a severe fatigue, nausea, ..... see more

  • Saved

Commented on 's Post

Efficacy and safety of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer (NSCLC): a systematic literature review

ABSTRACT ABSTRACT Therapeutic strategies with immune checkpoint inhibitors (ICIs) counteract the immunosuppressive effects of programmed cell death protein-1 (PD-1) and ligand-1 (PD-L1). ICI treatment has emerged in first- and second-line ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1774314

  • Saved

made a Post

Registration is now open for this free, live online event taking place Thursday 6/25 at 8pm EST.
see more

Managing Oncology Patients during and post-COVID-19

Two oncology specialists who treat patients in the NYC, NJ & Washington DC areas will share the COVID-19 impact on their institutional protocols/processes for inpatients and outpatients, the pandemic's potential ..... see more

Source : https://hopin.to/events/skipta-oncology-covid?ref=baeb4d35cfe3