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Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment

Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment

Source : https://doi.org/10.1080/2162402X.2020.1722023

ABSTRACT ABSTRACT Although anti-programmed death-1 (PD-1) treatment has shown remarkable anti-tumor efficacy, immune-related adverse events (irAEs) develop with heterogeneous clinical manifestations. However, the immunological understanding of irAEs is currently limited. .....

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Designer Probiotic Treatment for Cancer Immunotherapy

Designer Probiotic Treatment for Cancer Immunotherapy

Source : https://bme.columbia.edu/press-releases/designer-treatment-cancer-immunotherapy

New York, NY-February 12, 2020-Researchers at Columbia Engineering have engineered probiotics to safely deliver immunotherapies within tumors. These include nanobodies against two proven therapeutic targets-PD-L1 and CTLA-4. The drugs are .....

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Neoantigens in Hematologic Malignancies

Neoantigens in Hematologic Malignancies

Source : https://doi.org/10.3389/fimmu.2020.00121

T cell cancer neoantigens are created from peptides derived from cancer-specific aberrant proteins, such as mutated and fusion proteins, presented in complex with human leukocyte antigens on the cancer cell .....

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Cancer vaccine could boost the effectiveness of immunotherapy

Cancer vaccine could boost the effectiveness of immunotherapy

Source : https://www.eurekalert.org/pub_releases/2020-02/iocr-cvc020720.php

Supercharging the mutation rate in cancer cells can create a powerful vaccine that is able to boost the effectiveness of immunotherapy, a major new study reports. Scientists forced cancer cells .....

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PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer

PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer

Source : https://doi.org/10.1080/2162402X.2020.1711650

ABSTRACT Background: Although PD-1 blockade has significantly improved the survival of metastatic colorectal cancer with DNA Mismatch Repair-Deficient/Microsatellite Instability-High (MSI-H), the data on neoadjuvant setting is limited. Methods: In this .....

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New method to detect early-stage cancer identified

New method to detect early-stage cancer identified

Source : https://medicalxpress.com/news/2020-02-method-early-stage-cancer.html

A new method to detect cancer in its early stages using a targeted MRI contrast agent that binds to proteins has been identified by a team of researchers led by .....

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Mayo researchers discover way to prime cancer tumors for immunotherapy

Mayo researchers discover way to prime cancer tumors for immunotherapy

Source : https://newsnetwork.mayoclinic.org/discussion/mayo-researchers-discover-way-to-prime-cancer-tumors-for-immunotherapy/

ROCHESTER, Minn. ― A cancer tumor's ability to mutate allows it to escape from chemotherapy and other attempts to kill it. So, encouraging mutations would not be a logical path .....

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Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment

Identification of Therapeutic Targets and Prognostic Biomarkers Among CXC Chemokines in the Renal Cell Carcinoma Microenvironment

Source : https://doi.org/10.3389/fonc.2019.01555

Background: Renal cell carcinoma (RCC) is one of the most common malignances with an ever-increasing incidence and high mortality. Cross-talk between cancer cells and interstitial cells exerts significant effects on .....

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Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy

Source : https://doi.org/10.1080/2162402X.2020.1715767

ABSTRACT Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of .....

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A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Source : https://www.nature.com/articles/s41587-019-0403-9

Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the safety of .....