Skip to main content
micro-community-banner
 
  • Saved

made a Post

Relating Gut Microbiome and Its Modulating Factors to Immunotherapy in Solid Tumors: A Systematic Review

Background: Gut microbiome is proved to affect the activity of immunotherapy in certain tumors. see more

Source : https://doi.org/10.3389/fonc.2021.642110

  • Saved

made a Post

Characteristics of T-Cell Receptor Repertoire and Correlation With EGFR Mutations in All Stages of Lung Cancer

Lung cancer is the leading cause of cancer-related deaths worldwide, and its occurrence is related to the accumulation of gene mutations and immune escape of the tumor. Sequencing of the ..... see more

Source : https://doi.org/10.3389/fonc.2021.537735

  • Saved

made a Post

Characteristics of T-Cell Receptor Repertoire and Correlation With EGFR Mutations in All Stages of Lung Cancer

Lung cancer is the leading cause of cancer-related deaths worldwide, and its occurrence is related to the accumulation of gene mutations and immune escape of the tumor. Sequencing of the ..... see more

Source : https://doi.org/10.3389/fonc.2021.537735

  • Saved

made a Post

Cancer immunotherapy approach targets common genetic alteration

Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response ..... see more

Source : https://www.eurekalert.org/pub_releases/2021-03/jhm-cia031521.php

  • Saved

made a Post

Bispecific c-Met/PD-L1 CAR-T Cells Have Enhanced Therapeutic Effects on Hepatocellular Carcinoma

T cells expressing chimeric antigen receptors, especially CD19 CAR-T cells have exhibited effective antitumor activities in B cell malignancies, but due to several factors such as antigen escape effects and ..... see more

Source : https://doi.org/10.3389/fonc.2021.546586

  • Saved

made a Post

Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity

ABSTRACT ABSTRACT Treatment with an agonist anti-OX40 antibody (aOX40) boosts anti-tumor immunity by providing costimulation and driving effector T cell responses. However, tumor-induced immune suppression contributes significantly to poor response ..... see more

Source : https://doi.org/10.1080/2162402X.2021.1892265

  • Saved

made a Post

The Identification and Validation of Two Heterogenous Subtypes and a Risk Signature Based on Ferroptosis in Hepatocellular Carcinoma

BackgroundFerroptosis is essential for tumorigenesis and progression of hepatocellular carcinoma (HCC). The heterogeneity of ferroptosis and its relationship with tumor microenvironment (TME) have still remain elusive.MethodsBased on 74 ferroptosis related ..... see more

Source : https://doi.org/10.3389/fonc.2021.619242

  • Saved

made a Post

Engineered safety switch curbs severe side effects of CAR-T immunotherapy

UNC Lineberger Comprehensive Cancer Center researchers have demonstrated that an experimental safety switch incorporated as part of a chimeric antigen receptor-modified T cell therapy (CAR-T) was effective in reducing the ..... see more

Source : https://www.eurekalert.org/pub_releases/2021-03/ulcc-ess030321.php

  • Saved

made a Post

Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity

Reprogramming tumor infiltrating myeloid cells to elicit pro-inflammatory responses is an exciting therapeutic maneouver to improve anti-tumor responses. We recently demonstrated that a distinct microtubule-targeting drug, plinabulin-a clinical-stage novel agent-modulates ..... see more

Source : https://doi.org/10.3389/fonc.2021.644608

  • Saved

made a Post

Cyclooxygenase-2 Inhibitor: A Potential Combination Strategy With Immunotherapy in Cancer

The clinical application of immunotherapy is the milestone of cancer treatment. However, some patients have bad reaction. Cyclooxygenase-2 (COX-2) is frequently expressed in multiple cancer cells and is associated with ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fonc.2021.637504/full

  • Saved

made a Post

Systemic Immune-Inflammation Index and Changes of Neutrophil-Lymphocyte Ratio as Prognostic Biomarkers for Patients With Pancreatic Cancer Treated With Immune Checkpoint Blockade

The efficacy of current treatment regimens for pancreatic cancer (PC) remains unsatisfactory. In recent years, immune checkpoint blockade (ICB) therapy has shown promising anti-tumor outcomes in many malignancies, including PC. ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fonc.2021.585271/full

  • Saved

made a Post

Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas

The dynamics of PD-L1 expression are poorly understood over the development of lung adenocarcinomas from pre-invasive lesions to fully invasive carcinomas. Given the importance of PD-L1 expression for the selection ..... see more

Source : https://link.springer.com/article/10.1007/s00262-021-02883-x

  • Saved

made a Post

A Phase I Study of ASTX660, an Antagonist of Inhibitors of Apoptosis Proteins, in Adults with Advanced Cancers or Lymphoma

Purpose: This first-in-human, phase I study evaluated ASTX660, an oral, small-molecule antagonist of cellular/X-linked inhibitors of apoptosis proteins in patients with advanced solid tumors or lymphoma. Patients and Methods: ASTX660 ..... see more

Source : https://clincancerres.aacrjournals.org/content/26/12/2819

  • Saved

made a Post

Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Glioblastoma is the most malignant and lethal subtype of glioma. Despite progress in therapeutic approaches, issues with the tumor immune landscape persist. Multiple immunosuppression pathways coexist in the tumor microenvironment, ..... see more

Source : https://doi.org/10.3389/fonc.2020.617385

  • Saved

made a Post

Comprehensive Analysis of CDCAs Methylation and Immune Infiltrates in Hepatocellular Carcinoma

BackgroundAs essential components of cycle growth, the cell division cycle-associated family genes (CDCAs) have crucial roles in tumor development and progression, especially in hepatocellular carcinoma (HCC). However, due to the ..... see more

Source : https://doi.org/10.3389/fonc.2020.566183

  • Saved

made a Post

Statistical Considerations in the Evaluation of Continuous Biomarkers - PubMed

Discovery of biomarkers has been steadily increasing over the past decade. While a plethora of biomarkers have been reported in the biomedical literature, few have been sufficiently validated for broader ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33579807/

  • Saved

made a Post

Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Glioblastoma is the most malignant and lethal subtype of glioma. Despite progress in therapeutic approaches, issues with the tumor immune landscape persist. Multiple immunosuppression pathways coexist in the tumor microenvironment, ..... see more

Source : https://doi.org/10.3389/fonc.2020.617385

  • Saved

made a Post

Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

ABSTRACT The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and ..... see more

Source : https://doi.org/10.1080/2162402X.2021.1873585

  • Saved

made a Post

Biomarkers of Checkpoint Inhibitor Induced Immune-Related Adverse Events-A Comprehensive Review

Immune checkpoint inhibitors (ICIs) have substantially improved the prognosis of patients with different types of cancer. Through blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 ..... see more

Source : https://doi.org/10.3389/fonc.2020.585311