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Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas

The dynamics of PD-L1 expression are poorly understood over the development of lung adenocarcinomas from pre-invasive lesions to fully invasive carcinomas. Given the importance of PD-L1 expression for the selection ..... see more

Source : https://link.springer.com/article/10.1007/s00262-021-02883-x

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A Phase I Study of ASTX660, an Antagonist of Inhibitors of Apoptosis Proteins, in Adults with Advanced Cancers or Lymphoma

Purpose: This first-in-human, phase I study evaluated ASTX660, an oral, small-molecule antagonist of cellular/X-linked inhibitors of apoptosis proteins in patients with advanced solid tumors or lymphoma. Patients and Methods: ASTX660 ..... see more

Source : https://clincancerres.aacrjournals.org/content/26/12/2819

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Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Glioblastoma is the most malignant and lethal subtype of glioma. Despite progress in therapeutic approaches, issues with the tumor immune landscape persist. Multiple immunosuppression pathways coexist in the tumor microenvironment, ..... see more

Source : https://doi.org/10.3389/fonc.2020.617385

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Comprehensive Analysis of CDCAs Methylation and Immune Infiltrates in Hepatocellular Carcinoma

BackgroundAs essential components of cycle growth, the cell division cycle-associated family genes (CDCAs) have crucial roles in tumor development and progression, especially in hepatocellular carcinoma (HCC). However, due to the ..... see more

Source : https://doi.org/10.3389/fonc.2020.566183

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Statistical Considerations in the Evaluation of Continuous Biomarkers - PubMed

Discovery of biomarkers has been steadily increasing over the past decade. While a plethora of biomarkers have been reported in the biomedical literature, few have been sufficiently validated for broader ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33579807/

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Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Glioblastoma is the most malignant and lethal subtype of glioma. Despite progress in therapeutic approaches, issues with the tumor immune landscape persist. Multiple immunosuppression pathways coexist in the tumor microenvironment, ..... see more

Source : https://doi.org/10.3389/fonc.2020.617385

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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

ABSTRACT The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and ..... see more

Source : https://doi.org/10.1080/2162402X.2021.1873585

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Biomarkers of Checkpoint Inhibitor Induced Immune-Related Adverse Events-A Comprehensive Review

Immune checkpoint inhibitors (ICIs) have substantially improved the prognosis of patients with different types of cancer. Through blockade of cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 ..... see more

Source : https://doi.org/10.3389/fonc.2020.585311

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Integrative Analysis of Complement System to Prognosis and Immune Infiltrating in Colon Cancer and Gastric Cancer

BackgroundThe complement system acts as an integral part of the innate immune response, which acts primarily to remove pathogens and injured cells. Emerging evidence has shown the activation of the ..... see more

Source : https://doi.org/10.3389/fonc.2020.553297

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Case Report: Pseudoprogression With Nivolumab and Bevacizumab Followed by Recurrent Immune-Related Pneumonitis in Urothelial Carcinoma With Lung Metastasis

BackgroundCombination therapy with immune checkpoint inhibitors (ICIs) and antiangiogenic agents is generally effective and well tolerated and might be effective for metastatic urothelial carcinoma (UC). However, ICI treatment is often ..... see more

Source : https://doi.org/10.3389/fonc.2020.611810