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EARLY CHANGES IN IMMUNE CELL SUBSETS WITH CORTICOSTEROIDS IN PATIENTS WITH SOLID TUMORS: IMPLICATIONS FOR COVID-19 MANAGEMENT

The Journal for ImmunoTherapy of Cancer (JITC) is the official open access, peer-reviewed online journal of the Society for Immunotherapy of Cancer. The publication features original research articles, literature reviews, ..... see more

Source : https://www.sitcancer.org/research/jitc

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Tumor-infiltrating podoplanin+ cells in gastric cancer: clinical outcomes and association with immune contexture

ABSTRACT ABSTRACT Podoplanin (PDPN) has been proved to have significant immunoregulatory effects in several types of malignancies and is considered to be a novel immune checkpoint molecule. However, the clinical ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1845038

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Anti-human CD99 antibody exerts potent antitumor effects in mantle cell lymphoma

CD99 is a surface molecule expressed on various cell types including cancer cells. Expression of CD99 on multiple myeloma is associated with CCND1-IGH fusion/t(11;14). This translocation has been reported to ..... see more

Source : https://link.springer.com/article/10.1007/s00262-020-02789-0

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Novel galenic formulations for delivering immunochemotherapies: kill intelligently, remove the checkpoint and let the T cells in!

Anticancer immunotherapy has revolutionized the clinical routine of antineoplastic regimen offering novel treatment options for patients with advanced and therapy-resistant disease. In particular immune checkpoint blockade (ICB) with monoclonal antibodies ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1846358

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Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse

ABSTRACT Therapeutic cancer vaccines aim to induce an effective immune response against cancer, and the effectiveness of these vaccines is influenced by the choice of immunogen, vaccine type, and immunization ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1841392

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Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2]

ABSTRACT We had conducted phase 1/2 studies of cancer vaccination therapy using neo-tumor antigens in patients with refractory/persistent cervical cancer (CC) and ovarian cancer (OC) to assess the feasibility and ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1838189

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Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2]

ABSTRACT We had conducted phase 1/2 studies of cancer vaccination therapy using neo-tumor antigens in patients with refractory/persistent cervical cancer (CC) and ovarian cancer (OC) to assess the feasibility and ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1838189

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PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy

Background Clinical benefit from programmed cell death 1 receptor (PD-1) inhibitors relies on reinvigoration of endogenous antitumor immunity. Nonetheless, robust immunological markers, based on circulating immune cell subsets associated with ..... see more

Source : https://jitc.bmj.com/content/8/2/e001631

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Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy

Objectives Strategies to improve the responsiveness of programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade therapy remain an essential topic in cancer immunotherapy. In this study, we developed a new ..... see more

Source : https://jitc.bmj.com/content/8/2/e001156?rss=1

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Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment

AimThe role of spindle and kinetochore-associated (SKA) genes in tumorigenesis and cancer progression has been widely studied. However, so far, the oncogenic involvement of SKA family genes in pancreatic cancer ..... see more

Source : https://doi.org/10.3389/fonc.2020.553536