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CD4 T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy
Source : https://cancerimmunolres.aacrjournals.org/content/8/3/334
Accumulating evidence indicates that CD8 T cells in the tumor microenvironment and systemic CD4 T-cell immunity play an important role in mediating durable antitumor responses. We longitudinally examined .....
B cell-Derived IL35 Drives STAT3-Dependent CD8 T-cell Exclusion in Pancreatic Cancer
Source : https://cancerimmunolres.aacrjournals.org/content/8/3/292
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by a paucity of tumor-proximal CD8 T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8 T-cell .....
Treatment-Related Adverse Events of Combination Immune Checkpoint Inhibitors: Systematic Review and Meta-Analysis
Source : https://doi.org/10.3389/fonc.2020.00258
Background: Although clinical practice guidelines for the management of Immune Checkpoint Inhibitor (ICI)-related adverse events have recently been published, precise and nuanced toxicity data for combination ICI therapy are lacking. .....
LAG-3 and PD-1 LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures
Source : https://doi.org/10.1080/2162402X.2020.1736792
ABSTRACT Despite the success of immunotherapy using checkpoint blockade, many patients with solid tumors remain refractory to these treatments. In human cancer, the experimental options to investigate the specific effects .....
Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk
Source : https://doi.org/10.3389/fonc.2020.00324
Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidence forecasts that .....
Intratumor Heterogeneity in Early Lung Adenocarcinoma
Source : https://doi.org/10.3389/fonc.2020.00349
Lung cancer is one of the deadliest diseases in the world and is the leading cause of cancer-related deaths. Among the histological types, adenocarcinoma is the most common, and it .....
A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinoma
Source : https://doi.org/10.1080/2162402X.2020.1731943
ABSTRACT The tumor-suppressor gene tumor protein p53 ( TP53) is one of the most commonly mutated genes in human lung cancer, and TP53 mutations are associated with a worsened prognosis .....
