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Immunotherapy of Pediatric Solid Tumors: Treatments at a Crossroads, with an Emphasis on Antibodies

Immunotherapy of Pediatric Solid Tumors: Treatments at a Crossroads, with an Emphasis on Antibodies

Source : https://cancerimmunolres.aacrjournals.org/content/8/2/161

Over the last decade, immunotherapy has rapidly changed the therapeutic landscape and prognosis for many hematologic malignancies and adult solid tumors. Despite this success, immunotherapy for pediatric solid tumors remains .....

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Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens

Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1726168

ABSTRACT Oncolytic viruses represent a promising therapeutic modality, but they have yet to live up to their therapeutic potential. Safety and efficacy concerns impel us to identify least toxic oncolytic .....

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Targeting Natural Killer Cells for Tumor Immunotherapy

Targeting Natural Killer Cells for Tumor Immunotherapy

Source : https://doi.org/10.3389/fimmu.2020.00060

Natural killer (NK) cells are important innate cytotoxic lymphocytes with a rapid and efficient capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous- or allogeneic-activated .....

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Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds

Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1710052

ABSTRACT ABSTRACT Hundreds of trials are being conducted to evaluate combination of newer targeted drugs as well as immunotherapy. Our aim was to compare efficacy and safety of combination versus .....

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T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Source : https://doi.org/10.3389/fimmu.2020.00276

Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) .....

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Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion

Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion

Source : https://doi.org/10.3389/fimmu.2020.00007

The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due .....

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Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib

Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib

Source : https://doi.org/10.3389/fimmu.2020.00055

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival .....

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Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation

Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1724052

ABSTRACT ABSTRACT While anti-CEA antibodies have no direct effect on CEA-positive tumors, they can be used to direct potent anti-tumor effects as an antibody-IL-2 fusion protein (immunocytokine, ICK), and at .....

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Sponsored Content by Bristol-Myers Squibb

Need help educating your patients on how the immune system can help fight cancer?

To improve patient understanding about their BMS immunotherapy treatment, BMS has created the Immuno-Oncology Teach Initiative. This complimentary suite of multimedia tools allows patients to explore how their immunotherapy works and how patients can actively participate in their treatment. The suite features a reusable, in-office print Immuno-Oncology Teach Kit to help foster a better dialogue with your patients, including take-home patient resources, as well as a website that offers videos and other educational materials.


This program is sponsored by Bristol-Myers Squibb
IOUS1904204-01-01 1/20

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Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types

Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types

Source : https://doi.org/10.3389/fimmu.2020.00057

Background: Understanding how tumors subvert immune destruction is essential to the development of cancer immunotherapies. New evidence suggests that tumors limit anti-tumor immunity by exploiting transcriptional programs that regulate intratumoral .....