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Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition

ABSTRACT Checkpoint inhibitors have revolutionized cancer therapy and validated immunotherapy as an approach. Unfortunately, responses are seen in a minority of patients. Our objective is to use engineered adenoviruses designed ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1761229

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Tocilizumab, but not dexamethasone, prevents CRS without affecting antitumor activity of bispecific antibodies

Bispecific antibodies (bsAb) and chimeric antigen receptor (CAR) T cells allow for antibody guided recruitment of T cells against tumors. Both are successfully used for treatment of CD19 expressing leukemias, ..... see more

Source : https://jitc.bmj.com/content/8/1/e000621

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Anti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedule

ABSTRACT We previously reported that CIMAvax-EGF vaccine is safe, immunogenic and efficacious to treat advanced non-small-cell lung cancer (NSCLC) patients. A phase III trial was designed using an optimized immunization ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1762465

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Successful Anti-CLL1 CAR T-Cell Therapy in Secondary Acute Myeloid Leukemia

Secondary acute myeloid leukemia (sAML) is a high-risk AML evolving from heterogenous prior hematological disorders. Compared to de novo AML, sAML has even worse responses to current therapy and thus ..... see more

Source : https://doi.org/10.3389/fonc.2020.00685

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Mucosal inflammation predicts response to systemic steroids in immune checkpoint inhibitor colitis

Background Immune-related colitis is a common, often serious complication of immune checkpoint inhibition (ICI). Although endoscopy is not strictly recommended for any grade of diarrhea/colitis, emerging evidence suggests that endoscopic ..... see more

Source : https://jitc.bmj.com/content/8/1/e000451

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Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients - PubMed

We used quantitative shotgun DNA sequencing of fecal microbes as well as preclinical models of fecal or bacterial transfer to study the association between stool composition and (pre)clinical outcome to ..... see more

Source : https://www.ncbi.nlm.nih.gov/pubmed/32376136

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Extracellular Vesicles From Gastric Cancer Cells Induce PD-L1 Expression on Neutrophils to Suppress T-Cell Immunity

Neutrophils are prominent components of solid tumors and exhibit distinct phenotypes in different tumor milieu. We have previously shown that tumor extracellular vesicles (EVs) could induce pro-tumor activation of neutrophils; ..... see more

Source : https://doi.org/10.3389/fonc.2020.00629

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Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation

ABSTRACT A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1746553

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Genomic and immunologic correlates of LAG-3 expression in cancer

Immune checkpoint blockade leads to impressive and durable responses in multiple cancer types, and at present, both PD-1 and CTLA-4 blockade have been FDA approved for the treatment of several ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1756116

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Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer

Background New and fully validated tests need to be brought into clinical practice to improve the estimation of recurrence risk in patients with colon cancer. The aim of this study ..... see more

Source : https://jitc.bmj.com/content/8/1/e000272

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Optimized combinatorial pMHC class II multimer labeling for precision immune monitoring of tumor-specific CD4 T cells in patients

Background With immunotherapy gaining increasing approval for treatment of different tumor types, scientists rely on cutting edge methods for the monitoring of immune responses and biomarker development in patients. Due ..... see more

Source : https://jitc.bmj.com/content/8/1/e000435

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Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide

ABSTRACT ABSTRACT Triple-negative breast cancer (TNBC) is a highly metastatic and aggressive disease with limited treatment options. Recently, the combination of the immune checkpoint inhibitor (ICI) atezolizumab (anti-PD-L1) with nab-paclitaxel ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1760685

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Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3

ABSTRACT The success of CD8+ T cell-based cancer immunotherapy emphasizes the importance of understanding the mechanisms of generation of MHC-I peptide ligands and the possible pathways of tumor cell escape ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1761205

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A Role for MAIT Cells in Colorectal Cancer

MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT ..... see more

Source : https://doi.org/10.3389/fimmu.2020.00949

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60-Year-Old Female with Swollen, Painful Right Knee

A 60-year old female presents to her primary care physician complaining of a swollen and painful right knee. She reports ..... see more

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The Society for Immunotherapy in Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation

Objectives The interaction between the immune system and tumor cells is an important feature for the prognosis and treatment of cancer. Multiplex immunohistochemistry (mIHC) and multiplex immunofluorescence (mIF) analyses are ..... see more

Source : https://jitc.bmj.com/content/8/1/e000155

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Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model

ABSTRACT Recent advances in novel immune strategies, particularly chimeric antigen receptor (CAR)-bearing T-cells, have shown limited efficacy against glioblastoma (GBM) in clinical trials. We currently have an incomplete understanding of ..... see more

Source : https://doi.org/10.1080/2162402X.2020.1757360

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Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia

ABSTRACT Graft-versus-host disease (GvHD) remains a significant impediment to allogeneic hematopoietic cell transplantation (HCT) success, necessitating studies focused on alleviating GvHD, while preserving the graft-versus-leukemia (GvL) effect. see more

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1758011

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SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer

Background: Sirtuin 7 (SIRT7), a protein-coding gene whose abnormal expression and function are associated with carcinogenesis. However, the prognosis of SIRT7 in different breast cancer subtypes and its correlation with ..... see more

Source : https://doi.org/10.3389/fonc.2020.00621

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Measuring Intratumoral Heterogeneity of Immune Repertoires

There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures-along with the associated heterogeneity of the ..... see more

Source : https://doi.org/10.3389/fonc.2020.00512