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After adjusting for insurance type, treatment facility type, and other factors, Black individuals were more likely than their white counterparts to be diagnosed with the disease.

Black patients more likely to be diagnosed with late stage lung cancer, regardless of income, education level

Black Americans living in areas with the highest income and education levels were still more likely than white patients in the lowest education and income areas to have advanced-stage lung ..... see more

Source : https://thehill.com/changing-america/well-being/prevention-cures/3530115-black-patients-more-likely-to-be-diagnosed-with-late-stage-lung-cancer-regardless-of-income-education-level/amp/

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measuring TMB in ctDNA is a viable option for stratifying patients for immune checkpoint inhibitor

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

A blood-based tumor biomarker can predict the benefit of immunotherapy to patients with non-small cell lung cancer, according to a study published in Nature Medicine. The findings from this study ..... see more

Source : https://www.news-medical.net/amp/news/20220520/Blood-based-biomarker-can-predict-the-benefit-of-immunotherapy-to-lung-cancer-patients.aspx

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#.YnMjfiX3bDs

BioMark Diagnostics Raises C$1.5M to Commercialize Lung Cancer Liquid Biopsy Test

NEW YORK - Liquid biopsy firm BioMark Diagnostics said Wednesday that it has raised C$1.5 million (US$1.2 million) through a private financing round and new line of credit to help ..... see more

Source : https://www.genomeweb.com/business-news/biomark-diagnostics-raises-c15m-commercialize-lung-cancer-liquid-biopsy-test

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“There is a lot of good news, but I urge you all to roll up your sleeves. Let's use the therapies we have to help people live longer with the illness, live more normal lives with the illness, cure lung cancer, and try to prevent lung cancer through smoking cessation.”

A Year of Lung Cancer Improvements, With More Work To Do

This transcript has been edited for clarity. This is Mark Kris from Memorial Sloan Kettering, commenting today on the annual release of cancer statistics by Rebecca L. Siegel, MPH, and ..... see more

Source : https://www.medscape.com/viewarticle/967209

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Giving the immunotherapy Opdivo, made by Bristol Myers Squibb, to lung cancer patients before surgery can help prevent the disease from coming back, a new study says.

Giving immunotherapy before surgery prevents lung cancer from returning, study says

iving the immunotherapy Opdivo, made by Bristol Myers Squibb, to lung cancer patients before surgery can help prevent the disease from coming back, a new study says. It's a step ..... see more

Source : https://www.statnews.com/2022/04/11/opdivo-lung-cancer-surgery/

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Merck's monoclonal antibody therapy Keytruda reduced the risk of early stage lung cancer returning or death by 24% in patients who had undergone surgery, according to clinical trial data.

Merck's Keytruda reduced risk of disease recurrence or death in early lung cancer patients by 24%

Merck's antibody therapy for early stage lung cancer patients who have previously undergone surgery to have tumors removed reduced the risk of the disease returning again or the patient dying ..... see more

Source : https://www.google.com/amp/s/www.cnbc.com/amp/2022/03/17/mercks-keytruda-reduced-risk-of-recurrence-or-death-in-early-lung-cancer-patients-by-24percent.html

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New study shows the interaction of CD4 T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Immunotherapy Co-Opts Physically Interacting Cells in Lung Tumors

A new study defines a key subset of T cells in the microenvironment of human lung cancer that physically interact and directly communicate with antigen presenting dendritic cells to protect ..... see more

Source : https://www.genengnews.com/topics/cancer/immunotherapy-co-opts-physically-interacting-cells-in-lung-tumors/

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A major advance for patients with early stage non-small cell lung cancer with the FDA approval of neoadjuvant chemotherapy nivolumab based on CheckMate-816.

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Results showed the nivolumab-chemotherapy combination significantly improved EFS and pathologic complete response.

FDA grants priority review to Opdivo for non-small cell lung cancer indication

The FDA granted priority review to nivolumab for use with chemotherapy as neoadjuvant treatment of patients with resectable non-small cell lung cancer.Nivolumab (Opdivo, Bristol Myers Squibb), a PD-1 immune checkpoint ..... see more

Source : https://www.healio.com/news/hematology-oncology/20220228/fda-grants-priority-review-to-opdivo-for-nonsmall-cell-lung-cancer-indication

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Targeting KIX could offer a way to treat SCLC.

Surprise Discovery Suggests New Treatment for Small-Cell Lung Cancer

An unexpected discovery at UVA Cancer Center has allowed scientists to halt the development of small-cell lung cancer in lab mice, and the surprise finding could open the door to ..... see more

Source : https://newsroom.uvahealth.com/2022/02/24/surprise-discovery-suggests-new-treatment-for-small-cell-lung-cancer/

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This is worth watching. I had the honor of knowing Linnea and collaborating with her.

Linnea Olson: An Appreciation

Linnea Olson, a cancer activist, artist and blogger, who has lived with advanced lung cancer for 14 years, helps teach audiences about the patient experience in our executive education programs. ..... see more

Source : https://executiveeducation.hms.harvard.edu/linnea-olson-appreciation

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T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma - PubMed

Severe immune-related adverse events (irAEs) occur in up to 60% of patients with melanoma treated with immune checkpoint inhibitors (ICIs). However, it is unknown whether a common baseline immunological state ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35027754/



Conclusion/Relevance: “These results demonstrate circulating T cell characteristics associated with ICI-induced toxicity, with implications for improved diagnostics and clinical management.”

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HLA-independent T cell receptors for targeting tumors with low antigen density - Nature Medicine

HLA-independent T cell receptors, in which the heavy and light chains of a chimeric antigen receptor are incorporated into the endogenous T cell receptor locus, are more effective than CD28-based ..... see more

Source : https://www.nature.com/articles/s41591-021-01621-1



"Tumor escape associated with low target antigen expression is emerging as one potential limitation of their efficacy. Here we edit the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor–CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR....

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Precision medicine and immunotherapy have been game changers.

Cancer mortality rates continue to decline amid 'major progress' in lung cancer early detection and treatment

Cancer mortality rates have been dropping for nearly two decades, aided by "major progress" in the early detection and treatment options for lung cancer, according to the American Cancer Society's ..... see more

Source : https://www.google.com/amp/s/amp.cnn.com/cnn/2022/01/12/health/cancer-rates-lung-cancer-progress/index.html

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Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study - PubMed

doi: 10.1200/JCO.21.01874. Online ahead of print. 1 Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center and The James Comprehensive Cancer Center, Columbus, OH. 2 Department of Medical ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34990208/


Conclusion: Pembrolizumab demonstrated robust and durable antitumor activity and encouraging survival outcomes with manageable toxicity in patients with previously treated, advanced MSI-H/dMMR endometrial cancer.

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The renal clear cell carcinoma immune landscape

A comprehensive evaluation of the clear cell renal cell carcinoma (ccRCC) immune landscape was found using 584 RNA-sequencing datasets from The Cancer Genome Atlas (TCGA), we identified 17 key dysregulated ..... see more

Source : https://www.sciencedirect.com/science/article/pii/S1476558621001111?via=ihub


Relevance: Our study may lend novel insights into the clinical implications of immune dysregulation in ccRCC and suggests potential immunotherapeutic targets for further evaluation.

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The EPICAL trial, a phase Ib study combining first line afatinib with anti-EGF vaccination in EGFR-mutant metastatic NSCLC - PubMed

doi: 10.1016/j.lungcan.2021.12.014. Online ahead of print. 1 Medical Oncology, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34971901/



Conclusions: Combination treatment with an anti-EGF vaccine is well tolerated; induces a sustained immunogenic effect and might enhance the clinical efficacy of EGFR TKIs.

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Clinical characteristics and prognostic model for extensive-stage small cell lung cancer: A retrospective study over an 8-year period - PubMed

The first-line treatment of SCLC patients admitted to our hospital in the past 8 years was relatively standardized, and the progression-free survival and OS were slightly longer than those reported ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34970848/



Conclusions: The first-line treatment of SCLC patients admitted to our hospital in the past 8 years was relatively standardized, and the progression-free survival and OS were slightly longer than those reported in the literature. We developed a prognostic risk score model for extensive-stage SCLC to calculate individual survival in clinical...