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In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma

In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma

Source : https://doi.org/10.1080/2162402X.2019.1708066

ABSTRACTWhereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local i...

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Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8  T Cells in Langerhans Cell Histiocytosis

Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8 T Cells in Langerhans Cell Histiocytosis

Source : https://doi.org/10.3389/fimmu.2019.03045

Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder of hematopoietic origin characterized by inflammatory lesions containing clonal histiocytes (LCH-cells) intermixed with various immune cells, including T cells. In 50-60% of .....

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ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer

ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer

Source : https://doi.org/10.1080/2162402X.2019.1710398

(2020). ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer. OncoImmunology: Vol. 9, .....

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High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

Source : https://doi.org/10.3389/fimmu.2019.03016

CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-MHC, i.e., the TCR binding avidity. A current challenge in onco-immunology lies in the evaluation of vaccine protocols .....

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Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Source : https://doi.org/10.1080/2162402X.2019.1703449

ABSTRACT ABSTRACT The term 'immunogenic cell death' (ICD) denotes an immunologically unique type of regulated cell death that enables, rather than suppresses, T cell-driven immune responses that are specific for .....

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Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer

Source : https://doi.org/10.3389/fimmu.2019.03023

Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a significant minority is caused by Lynch syndrome (LS). .....

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In top-line final Phase III results from KEYNOTE-604, Keytruda improves PFS but not OS when combined with chemotherapy for the first-line treatment of small-cell lung cancer.

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Novartis and Gilead longer-term data show largely steady response and survival rates, shoring up the clinical and commercial case for their products and justifying continued investment in T-cell therapies. The .....

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Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Source : https://www.pnas.org/content/early/2019/12/26/1904022116

Immunotherapy has revolutionized cancer treatment, yielding unprecedented long-term responses and survival. However, a significant proportion of patients remain refractory, which correlates with the absence of immune-infiltrated ("hot") tumors. Here, we .....

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High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation

High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0816-5

B7-H3 and B7-H4 are highly expressed by many human malignancies making them attractive immunotherapeutic targets. However, their expression patterns and immune contexts in epithelial ovarian cancer have not been well .....

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Let's Talk About BiTEs and Other Drugs in the Real-Life Setting for B-Cell Acute Lymphoblastic Leukemia

Let's Talk About BiTEs and Other Drugs in the Real-Life Setting for B-Cell Acute Lymphoblastic Leukemia

Source : https://doi.org/10.3389/fimmu.2019.02856

Background: Therapy for acute lymphoblastic leukemia (ALL) are currently initially efficient, but even if a high percentage of patients have an initial complete remission (CR), most of them relapse.

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Indirect impact of PD-1/PD-L1 blockade on a murine model of NK cell exhaustion

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2020.00007/abstract

The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due .....

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A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer

A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1685300

ABSTRACT ABSTRACT Cancer immunotherapy continues to make headway as a treatment for advanced stage tumors, revealing an urgent need to understand the fundamentals of anti-tumor immune responses. Noteworthy is a .....

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The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy

Source : https://doi.org/10.3389/fimmu.2019.02934

Intensive fundamental and clinical research in cancer immunotherapy has led to the emergence and evolution of two parallel universes with surprisingly little interactions: the realm of hematologic malignancies and that .....

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Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

Source : https://doi.org/10.1080/2162402X.2019.1682381

ABSTRACT ABSTRACT A substantial obstacle to the success of adoptive T cell-based cancer immunotherapy is the sub-optimal affinity of T-cell receptors (TCRs) for most tumor antigens. Genetically engineered TCRs that .....

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Genetic Modification of CD8  T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Genetic Modification of CD8 T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies

Source : https://doi.org/10.3389/fimmu.2019.02990

Adoptive immunotherapy with ex vivo-expanded tumor-infiltrating lymphocytes (TILs) has achieved objective clinical responses in a significant number of patients with cancer. The failure of many patients to develop long-term tumor .....

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Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma

Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma

Source : https://doi.org/10.1080/2162402X.2019.1676615

ABSTRACTMultiple rodent and primate preclinical studies have advanced CAR T cells into the clinic. However, no single model accurately reflects the challenges of effective CAR T therapy in human ca...

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Neoantigens in Hematological Malignancies-Ultimate Targets for Immunotherapy?

Neoantigens in Hematological Malignancies-Ultimate Targets for Immunotherapy?

Source : https://doi.org/10.3389/fimmu.2019.03004

Neoantigens derive from non-synonymous somatic mutations in malignant cells. Recognition of neoantigens presented via human leukocyte antigen (HLA) molecules on the tumor cell surface by T cells holds promise to .....

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Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

Source : https://doi.org/10.3389/fimmu.2019.02872

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds to receptors belonging .....

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CAIX-specific CAR-T Cells and Sunitinib Show Synergistic... : Journal of Immunotherapy

CAIX-specific CAR-T Cells and Sunitinib Show Synergistic... : Journal of Immunotherapy

Source : https://journals.lww.com/immunotherapy-journal/Abstract/2020/01000/CAIX_specific_CAR_T_Cells_and_Sunitinib_Show.3.aspx

efficacy. Some chemotherapeutic agents exhibit immune microenvironment modulation. Therefore, combination with chemotherapeutic agents may be one of the promising strategies to enhance the therapeutic efficacy of CAR-T against solid tumors. .....

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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector

Source : https://doi.org/10.3389/fimmu.2019.02873

NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors (BaEV-LVs) encoding eGFP, we obtained a transduction rate of 23.0 .....

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A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer

A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer

Source : https://doi.org/10.1080/2162402X.2019.1685300

ABSTRACT ABSTRACT Cancer immunotherapy continues to make headway as a treatment for advanced stage tumors, revealing an urgent need to understand the fundamentals of anti-tumor immune responses. Noteworthy is a .....

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The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment

The Interplay Between Innate Lymphoid Cells and the Tumor Microenvironment

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02895/full

The multifaceted roles of Innate Lymphoid Cells (ILC) have been widely interrogated in tumor immunity. Whereas, Natural Killer (NK) cells possess undisputable tumor-suppressive properties across multiple types of cancer, the .....

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A 56-year old woman is admitted to the hospital with a two-day history of temperature up to 104.6 degrees, joint pain and nausea.

Her history includes a diagnosis of .....

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Enhanced Anti-melanoma Efficacy of a Pim-3-Targeting Bifunctional Small Hairpin RNA via Single-Stranded RNA-Mediated Activation of Plasmacytoid Dendritic Cells

Enhanced Anti-melanoma Efficacy of a Pim-3-Targeting Bifunctional Small Hairpin RNA via Single-Stranded RNA-Mediated Activation of Plasmacytoid Dendritic Cells

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02721/full

Melanoma is the most serious type of skin cancer. The immunosuppressive tumor microenvironment and aberrant expression of some proto-oncogenes are the main cause of melanoma development. We have constructed a .....

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Donor-Derived CD123-Targeted CAR T Cell Serves as a RIC Regimen for Haploidentical Transplantation in a Patient With FUS-ERG  AML

Donor-Derived CD123-Targeted CAR T Cell Serves as a RIC Regimen for Haploidentical Transplantation in a Patient With FUS-ERG AML

Source : https://doi.org/10.3389/fonc.2019.01358

Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) following chemotherapy is part of standard treatment protocol for patients with acute myeloid leukemia (AML). FUS-ERG AML is rare but has an .....

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A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer

A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer

Source : https://doi.org/10.1080/2162402X.2019.1685300

ABSTRACT ABSTRACT Cancer immunotherapy continues to make headway as a treatment for advanced stage tumors, revealing an urgent need to understand the fundamentals of anti-tumor immune responses. Noteworthy is a .....

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UCLA study shows inhibition of gene helps overcome resistance to immunotherapy

UCLA study shows inhibition of gene helps overcome resistance to immunotherapy

Source : http://newsroom.ucla.edu/releases/ucla-study-gene-inhibition-cancer-immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, .....

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Harnessing NK Cells for Cancer Treatment

Harnessing NK Cells for Cancer Treatment

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02836/full

In the last years, natural killer (NK) cell-based immunotherapy has emerged as a promising therapeutic approach for solid tumors and hematological malignancies. NK cells are innate lymphocytes with an array .....

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CD19 and CD70 Dual-Target Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Relapsed and Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma

CD19 and CD70 Dual-Target Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Relapsed and Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma

Source : https://doi.org/10.3389/fonc.2019.01350

Background: The therapeutic efficacy of chimeric antigen receptor (CAR) T-cells targeting CD19 has been illustrated in the treatment of diffuse large B-cell lymphoma (DLBCL). However, there is a 21-35% relapse .....

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Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells

Molecular Design, Optimization, and Genomic Integration of Chimeric B Cell Receptors in Murine B Cells

Source : https://doi.org/10.3389/fimmu.2019.02630

Immune cell therapies based on the integration of synthetic antigen receptors comprise a powerful strategy for the treatment of diverse diseases, most notably T cells engineered to express chimeric antigen .....

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Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

Source : https://doi.org/10.1080/2162402X.2019.1682381

ABSTRACT ABSTRACT A substantial obstacle to the success of adoptive T cell-based cancer immunotherapy is the sub-optimal affinity of T-cell receptors (TCRs) for most tumor antigens. Genetically engineered TCRs that .....

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Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment

Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment

Source : https://doi.org/10.3389/fimmu.2019.02746

For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was slowly replaced by the understanding that .....

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A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

Source : https://doi.org/10.1080/2162402X.2019.1678921

ABSTRACT ABSTRACT Immunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing oncolytic virotherapy is a lack .....

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Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer

Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer

Source : https://doi.org/10.3389/fimmu.2019.02693

Immunotherapy, which is seen as a major tool for cancer treatment, requires, in some cases, the presence of several agents to maximize its effects. Adjuvants can enhance the effect of .....

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TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

Source : https://doi.org/10.1080/2162402X.2019.1681869

ABSTRACT ABSTRACT IL-2 is a pleiotropic cytokine that plays an essential role in the survival, expansion, and function of CD8 T cells, regulatory T cells (Tregs), and natural killer (NK) .....

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Neoantigen Fitness Model Predicts Lower Immune Recognition of Cutaneous Squamous Cell Carcinomas Than Actinic Keratoses

Neoantigen Fitness Model Predicts Lower Immune Recognition of Cutaneous Squamous Cell Carcinomas Than Actinic Keratoses

Source : https://doi.org/10.3389/fimmu.2019.02799

A low percentage of actinic keratoses progress to develop into cutaneous squamous cell carcinoma. The immune mechanisms that successfully control or eliminate the majority of actinic keratoses and the mechanisms .....

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A 68-year-old woman with recurrent cutaneous SCC (CSCC) over the past two years felt an axillary mass beneath in her left armpit while showering. A CT scan of her chest .....

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Expression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects

Expression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1651622

ABSTRACTCD137-targeting immune therapy, which activates anti-tumor T effector cell responses, seems to be an attractive concept in clinical oncology. Recent evidence has demonstrated that tumor cel...

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Using artificial intelligence to determine whether immunotherapy is working

Source : https://www.sciencedaily.com/releases/2019/11/191123100631.htm

Currently, only about 20% of all cancer patients will actually benefit from costly immunotherapy. New research can now determine which ones are in that category, simply by analyzing previously unseen .....

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Analysis of Secondary Structure Biases in Naturally Presented HLA-I Ligands

Analysis of Secondary Structure Biases in Naturally Presented HLA-I Ligands

Source : https://doi.org/10.3389/fimmu.2019.02731

Recent clinical developments in antitumor immunotherapy involving T-cell related therapeutics have led to a renewed interest for human leukocyte antigen class I (HLA-I) binding peptides, given their potential use as .....

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Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

Universal Ready-to-Use Immunotherapeutic Approach for the Treatment of Cancer: Expanded and Activated Polyclonal γδ Memory T Cells

Source : https://doi.org/10.3389/fimmu.2019.02717

In the last years, important progresses have been registered in the treatment of patients suffering from oncological/haematological malignancies, but more still needs to be done to reduce toxicity and side .....

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The density and spatial tissue distribution of CD8   and CD163   immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

The density and spatial tissue distribution of CD8 and CD163 immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0797-4

Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to treatment clinical benefit, the pre-existing .....

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Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma.

Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31652094

J Clin Oncol. 2019 Oct 25:JCO1901740. doi: 10.1200/JCO.19.01740. [Epub ahead of print]

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Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer

Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer

Source : https://doi.org/10.1080/2162402X.2019.1677427

ABSTRACTImmunosurveillance plays an important role in breast cancer (BC) prognosis and progression, and can be geared by immunogenic chemotherapy. In a cohort of 1023 BC patients treated with neoad...

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Scientists build machine learning-based algorithm to predict which cancer patients benefit from immunotherapy

Scientists build machine learning-based algorithm to predict which cancer patients benefit from immunotherapy

Source : https://www.irbbarcelona.org/en/news/scientists-build-machine-learning-based-algorithm-to-predict-which-cancer-patients-benefit-from

Scientists at the Institute for Research in Biomedicine (IRB Barcelona), in collaboration with the Centre for Genomic Regulation (CRG) and Radboud University, have developed an algorithm that can predict which .....

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Mass Cytometry Imaging for the Study of Human Diseases-Applications and Data Analysis Strategies

Mass Cytometry Imaging for the Study of Human Diseases-Applications and Data Analysis Strategies

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02657/full

High parameter imaging is an important tool in the life sciences for both discovery and healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging (MIBI) are two relatively .....

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An in silico-in vitro Pipeline Identifying an HLA-A*02:01  KRAS G12V  Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients

An in silico-in vitro Pipeline Identifying an HLA-A*02:01 KRAS G12V Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients

Source : https://doi.org/10.3389/fimmu.2019.02572

Targeting CD8 T cells to recurrent tumor-specific mutations can profoundly contribute to cancer treatment. Some of these mutations are potential tumor antigens although they can be displayed by non-spliced .....

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GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells

GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells

Source : https://doi.org/10.1080/2162402X.2019.1683345

ABSTRACTExpression of the disialoganglioside GD2 has been identified as a marker antigen associated with a breast cancer stem-like cell (BCSC) phenotype. Here, we report on the evaluation of GD2 as...

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Immune System Evasion as Hallmark of Melanoma Progression: The Role of Dendritic Cells

Immune System Evasion as Hallmark of Melanoma Progression: The Role of Dendritic Cells

Source : https://www.frontiersin.org/articles/10.3389/fonc.2019.01148/full

Melanoma is an immunogenic tumor whose relationship with immune cells resident in the microenvironment significantly influences cancer cell proliferation, progression, and metastasis. During melanomagenesis, both immune and melanoma cells undergo .....

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Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer

Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1682380

ABSTRACTOncogenic KRAS-mutant lung cancers remain treatment refractory. A better understanding of the immune response of KRAS-mutant lung cancers is required to facilitate the development of potent...

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GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up

Source : https://doi.org/10.3389/fonc.2019.01102

Background: GOLFIG is a chemo-immunotherapy regimen established in preclinical models that combines gemcitabine FOLFOX (fluoropyrimidine backbone coupled to oxaliplatin) poly-chemotherapy with low-dose s. c. recombinant interleukin-2 (rIL-2) and .....

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Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets

Source : https://doi.org/10.3389/fonc.2019.01145

Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the .....

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The prognostic impact of immune-related adverse events during anti-PD1 treatment in melanoma and non-small-cell lung cancer: a real-life retrospective study

The prognostic impact of immune-related adverse events during anti-PD1 treatment in melanoma and non-small-cell lung cancer: a real-life retrospective study

Source : https://doi.org/10.1080/2162402X.2019.1682383

We conducted a retrospective cohort study in all consecutive patients treated with nivolumab or pembrolizumab off clinical trials at the Toulouse University Cancer Institute ( Institut Universitaire du Cancer de .....

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The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia

The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1683347

ABSTRACT Hematological malignancies possess a distinctive immunologic microenvironment compared with solid tumors. Here, using an established computational algorithm (CIBERSORT), we systematically analyzed the overall distribution of 22 tumor-infiltrating leukocyte (TIL) .....

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A 42-year female patient presents to her primary care physician complaining of low-grade fever, fatigue, and upper respiratory symptoms for the past week. She’s concerned that she may have the .....

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Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer

Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1671762

ABSTRACTThe efficacy of cancer immunotherapy may be improved by increasing the number of circulating tumor-reactive T cells. The bone marrow is a priming site and reservoir for such T cells. .....

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Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer

Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0765-z

The treatment of endometrial cancer (EC), the most common gynecological cancer, is currently hampered by the toxicity of current cytotoxic agents, meaning novel therapeutic approaches are urgently required. A cohort .....

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Mass Cytometry Reveals a Sustained Reduction in CD16  Natural Killer Cells Following Chemotherapy in Colorectal Cancer Patients

Mass Cytometry Reveals a Sustained Reduction in CD16 Natural Killer Cells Following Chemotherapy in Colorectal Cancer Patients

Source : https://doi.org/10.3389/fimmu.2019.02584

The immune system and inflammation plays a significant role in tumour immune evasion enhancing disease progression and reducing survival in colorectal cancer (CRC). Patients with advanced stages of colorectal cancer .....

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Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention

Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02557/full

Efficient clearance of transformed cells by Natural Killer (NK) cells is regulated by several activating receptors, including NKG2D, NCRs, and DNAM-1. Expression of these receptors as well as their specific .....

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Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0747-1

The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita. In particular, it remains unexplored how driver mutations could be associated with distinct TIBs .....

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A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry

A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry

Source : https://doi.org/10.3389/fimmu.2019.02534

Multiplex immunophenotyping technologies are indispensable for a deeper understanding of biological systems. Until recently, high-dimensional cellular analyses implied the loss of tissue context as they were mostly performed in single-cell .....

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Clues to improve cancer immunotherapy revealed: Helper T cells appear vital to more robust anti-tumor response

Source : https://www.sciencedaily.com/releases/2019/10/191023132242.htm

Cancer immunotherapy drugs trigger the body's immune system to attack tumors and have revolutionized the treatment of certain cancers, such as lymphoma, lung cancer and melanoma. Yet, while some patients .....

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Insights Into Mechanisms of Tumor and Immune System Interaction: Association With Wound Healing

Insights Into Mechanisms of Tumor and Immune System Interaction: Association With Wound Healing

Source : https://doi.org/10.3389/fonc.2019.01115

A large number of studies have presented a great deal of information about tumor and immune system interaction. Nevertheless, the problem of tumor evasion from the immune reaction is still .....

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Teamwork by different T-cell types boosts tumour destruction by immunotherapy

Teamwork by different T-cell types boosts tumour destruction by immunotherapy

Source : https://www.nature.com/articles/d41586-019-03106-1

Immunotherapy treatment harnesses CD8 T cells of the immune system to kill tumour cells. The finding that CD4 helper T cells contribute to the success of this treatment in mice .....

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A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer

A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer

Source : https://doi.org/10.3389/fonc.2019.01066

Background: Cancer patients often display dysfunctional antitumor T-cell responses. Because noteworthy benefits of immune checkpoint pathway blockade, such as programmed cell death protein 1 (PD-1) inhibitors, have been achieved in .....

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Toll-like receptor 3 -926T>A increased the risk of breast cancer through decreased transcriptional activity

Toll-like receptor 3 -926T>A increased the risk of breast cancer through decreased transcriptional activity

Source : https://doi.org/10.1080/2162402X.2019.1673126

ABSTRACT ABSTRACT Toll-like receptor 3 (TLR3) is a viral sensor that induces apoptosis in response to double-stranded RNA (dsRNA). Common genetic changes in the TLR3 gene may influence breast cancer .....

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MHC-II neoantigens shape tumour immunity and response to immunotherapy

MHC-II neoantigens shape tumour immunity and response to immunotherapy

Source : https://www.nature.com/articles/s41586-019-1671-8

The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can .....

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A 59-year old female was initially diagnosed with hemorrhoids. However, the pathology report from the hemorrhoidectomy revealed an over 20 mm high-grade melanoma with BRAF wild-type mutation and lymphovascular invasion. .....

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The promise of adoptive cellular immunotherapies in hepatocellular carcinoma

The promise of adoptive cellular immunotherapies in hepatocellular carcinoma

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1673129

ABSTRACT ABSTRACT Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Current systemic therapies result only in modest benefits and new therapeutic options are critically needed. .....

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Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

Source : https://doi.org/10.3389/fonc.2019.01040

Introduction: Therapeutic targeting of inhibitors of the immune response has reached the clinical setting. Inhibitors of the novel receptor LAG3, which negatively regulates T-cell activation, are under investigation. Here we .....

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Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

Source : https://doi.org/10.3389/fonc.2019.01040

Introduction: Therapeutic targeting of inhibitors of the immune response has reached the clinical setting. Inhibitors of the novel receptor LAG3, which negatively regulates T-cell activation, are under investigation. Here we .....

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Multi-omics Analysis of Microenvironment Characteristics and Immune Escape Mechanisms of Hepatocellular Carcinoma

Multi-omics Analysis of Microenvironment Characteristics and Immune Escape Mechanisms of Hepatocellular Carcinoma

Source : https://doi.org/10.3389/fonc.2019.01019

The immune environment in primary tumor has a profound impact on immunotherapy. However, the clinical relevance of immune environment in hepatocellular carcinoma (HCC) is largely unknown. Here, the immune profile .....

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Discovery of low-molecular weight anti-PD-L1 peptides for cancer immunotherapy

Discovery of low-molecular weight anti-PD-L1 peptides for cancer immunotherapy

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0705-y

Immunotherapy using checkpoint inhibitors, especially PD-1/PD-L1 inhibitors, has now evolved into the most promising therapy for cancer patients. However, most of these inhibitors are monoclonal antibodies, and their large size .....

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TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer

TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer

Source : https://doi.org/10.3389/fonc.2019.01002

In recent years, several newly identified T helper (TH) cell subsets, such as TH9, TH17, and TH22 cells, and their respective cytokine products, IL-9, IL-17, and IL-22, have been reported .....

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Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1673125

ABSTRACT The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze .....

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Inflammation, Cancer and Immunity-Implication of TRPV1 Channel

Inflammation, Cancer and Immunity-Implication of TRPV1 Channel

Source : https://doi.org/10.3389/fonc.2019.01087

Process of inflammation and complex interactions between immune and cancer cells within tumor microenvironment are known to drive and shape the outcome of the neoplastic disease. Recent studies increasingly show .....

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Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers

Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0737-3

Immune checkpoint inhibitors (ICIs) have achieved impressive success in different cancer types, yet responses vary and predictive biomarkers are urgently needed. Growing evidence points to a link between DNA methylation .....

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Rgenix, a New York-based start-up co-founded by three prominent physician researchers, is taking aim at what it contends is the future of cancer treatment:  finding drugs that shut off the .....

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Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery

Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery

Source : https://doi.org/10.1080/2162402X.2019.1670019

ABSTRACTOrganotypic tumor slices represent a physiologically-relevant culture system for studying the tumor microenvironment. Systematic characterization of the tumor slice culture system will enab...

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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients

T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients

Source : https://www.tandfonline.com/10.1080/2162402X.2019.1663107

ABSTRACT Advances within cancer immunotherapy have fueled a paradigm shift in cancer treatment, resulting in increasing numbers of cancer types benefitting from novel treatment options. Despite originally being considered an .....

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GMP-Compliant Manufacturing of NKG2D CAR Memory T Cells Using CliniMACS Prodigy

Source : https://doi.org/10.3389/fimmu.2019.02361

Natural killer group 2D (NKG2D) is a natural killer (NK) cell-activating receptor that recognizes different stress-induced ligands that are overexpressed in a variety of childhood and adult tumors. NKG2D chimeric .....

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Dendritic Cell Vaccination in Metastatic Melanoma Turns "Non-T Cell Inflamed" Into "T-Cell Inflamed" Tumors

Source : https://doi.org/10.3389/fimmu.2019.02353

Dendritic cell (DC)-based vaccination effectively induces anti-tumor immunity, although in the majority of cases this does not translate into a durable clinical response. However, DC vaccination is characterized by a .....

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Identification of novel, immune-mediating extracellular vesicles in human lymphatic effluent draining primary cutaneous melanoma

Source : https://doi.org/10.1080/2162402X.2019.1667742

ABSTRACTEpithelial tumors including melanoma often first metastasize to regional, sentinel lymph nodes (SLN). Thus, the presence of SLN metastases is a critical prognostic factor of survival. Prior...

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Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Source : https://doi.org/10.1080/2162402X.2019.1648170

(2019). Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile. OncoImmunology: Vol. 8, No. 11, e1648170.

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Expression of Programmed Cell Death-Ligands in Hepatocellular Carcinoma: Correlation With Immune Microenvironment and Survival Outcomes

Expression of Programmed Cell Death-Ligands in Hepatocellular Carcinoma: Correlation With Immune Microenvironment and Survival Outcomes

Source : https://doi.org/10.3389/fonc.2019.00883

The quantity of programmed cell death-ligand 1 (PD-L1) is regarded as a predicting factor of clinical response to anti-PD-1 axis immunotherapy. However, the expression of PD-L1 and its prognostic value .....

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Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Source : https://doi.org/10.1080/2162402X.2019.1641390

ABSTRACTDexamethasone is a synthetic glucocorticoid commonly used for the prevention and management of side effects in cancer patients undergoing chemotherapy. While it is effective as an anti-emet...

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Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells

Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells

Source : https://doi.org/10.3389/fonc.2019.00945

Hodgkin Lymphoma (HL) is a malignancy that frequently affects young adults. Although, there are effective treatments not every patient responds, necessitating the development of novel therapeutic approaches, especially for relapsed .....

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A 46-year-old male presents to his PCP, complaining of no appetite, dizziness, and fatigue. He reminds his PCP that he is receiving treatment for metastatic HCC with a PD-1 inhibitor. .....

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Opdivo showed a 23% fall in the risk of death and 2.5-month improvement in median overall survival compared to chemotherapy in Phase III esophageal cancer trial.

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Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma.

Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31552039

Front Immunol. 2019 Sep 4;10:2093. doi: 10.3389/fimmu.2019.02093. eCollection 2019.

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Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis.

Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31552050

Front Immunol. 2019 Sep 6;10:2120. doi: 10.3389/fimmu.2019.02120. eCollection 2019. Review

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Overall survival for patients with gastrointestinal stromal tumors (GIST) in the fourth-line setting was 15.1 months versus 6.6 months for placebo, building on impressive progression-free survival results.

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Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1648170

(2019). Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile. OncoImmunology: Vol. 8, No. 11, e1648170.

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Intriguing ecDNA research at UCSD, which could generate a tumor agnostic approach.….

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Closed system RT-qPCR as a potential companion diagnostic test for immunotherapy outcome in metastatic melanoma

Closed system RT-qPCR as a potential companion diagnostic test for immunotherapy outcome in metastatic melanoma

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0731-9

In melanoma, there is no companion diagnostic test to predict response to programmed cell death 1 (PD-1) axis immune checkpoint inhibitor (ICI) therapy. In the adjuvant setting, only one in .....

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Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1641390

ABSTRACTDexamethasone is a synthetic glucocorticoid commonly used for the prevention and management of side effects in cancer patients undergoing chemotherapy. While it is effective as an anti-emet...

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Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Source : https://www.nature.com/articles/s41467-019-12361-9

Immune-checkpoint inhibition therapy has achieved success in a subset of patients. Here the authors profiled about 200 relevant metabolites in patient serum samples from three independent immunotherapy trials and found .....

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Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1652532

ABSTRACT ABSTRACT Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of .....

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Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers

Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02215

Tumor-associated macrophages (TAMs) are a major component of the tumor immune microenvironment (TIME) and are associated with a poor prognostic factor in several cancers. TAMs promote tumor growth by facilitating .....

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Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer

Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer

Source : https://cancerimmunolres.aacrjournals.org/content/7/9/1412

Adoptive T-cell therapy using high-affinity T-cell receptors (TCR) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent .....

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Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition-A Pooled Analysis of Patients With Advanced Melanoma

Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition-A Pooled Analysis of Patients With Advanced Melanoma

Source : https://ascopubs.org/doi/full/10.1200/JCO.19.00345?af=R

PURPOSE Outcome measures that comprehensively capture attributes of immuno-oncology agents, including prolonged treatment-free time and persistent treatment-related adverse events (TRAEs), are needed to complement conventional survival end points. METHODS We .....

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Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma

Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02093/full

Background: CD38 is involved in the adenosine pathway, which represents one of the immunosuppressive mechanisms in cancer. CD38 is broadly expressed across immune cell subsets, including human macrophages differentiated in .....

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Structure Based Prediction of Neoantigen Immunogenicity

Structure Based Prediction of Neoantigen Immunogenicity

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02047/full

The development of immunological therapies that incorporate peptide antigens presented to T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated neoantigens are being explored .....

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Pre-surgical oncolytic virotherapy improves breast cancer outcomes

Pre-surgical oncolytic virotherapy improves breast cancer outcomes

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1655363

Cancer immunotherapies allow for immune cells to efficiently target cancers. While exciting clinical successes are observed using ICIs (antibodies that prevent the inhibition of immune cells) in cancers such as .....

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Altered Lipid Tumor Environment and Its Potential Effects on NKT Cell Function in Tumor Immunity

Altered Lipid Tumor Environment and Its Potential Effects on NKT Cell Function in Tumor Immunity

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02187/full

Natural killer T (NKT) cells are CD1d restricted T cells that mostly recognize lipid antigens. These cells share characteristics with both adaptive and innate immune cells and have multiple immunoregulatory .....

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Tumors vs. Chronic Wounds: An Immune Cell's Perspective

Tumors vs. Chronic Wounds: An Immune Cell's Perspective

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02178/full

The wound repair program is tightly regulated and coordinated among different cell constituents including epithelial cells, fibroblasts, immune cells and endothelial cells following consecutive steps to ensure timely, and proper .....

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Lack of infrastructure for identifying mutations and access routes is holding back use of targeted medicines in children with cancer

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A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1652539

ABSTRACT The combination of immune-stimulating strategies has the potency to improve immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor material can generate tumor-specific T cell immunity, which could .....

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The next frontier for cell therapy is solid tumors – and of the many attempts to move from liquid to solid tumors, tumor infiltrating lymphocytes and other CAR-T constructs are some .....

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Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy

Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02083/full

IntroductionThe advent of immunotherapy (IT), especially immune checkpoint blockers (ICBs), and its application in oncology has provided new hope for cancer patients. However, despite the rapid progress in the field .....

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Boehringer Ingelheim intends to combine Lupin’s MEK inhibitor with its own KRAS inhibitors to target the oncogenic KRAS-RAF-MEK-ERK pathway, mutations in which drive many difficult-to-treat cancers. Note: additional .....

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A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1657375

ABSTRACTWe have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents can be advantageously combined with fasting regimens or caloric restriction mimetics (CRMs) to ach...

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B cells linked to immunotherapy for melanoma

B cells linked to immunotherapy for melanoma

Source : https://www.ebi.ac.uk/about/news/press-releases/B-cells-immunotherapy

Summary 13 September, Cambridge - Researchers at EMBL's European Bioinformatics Institute and the Medical University of Vienna have found evidence that B cells might play an important role in immunotherapy .....

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From the Computer to the Clinic: Methods for the Prediction, Validation and Characterization of Tumor Neo-antigens for Applications in Cancer Immunotherapy

From the Computer to the Clinic: Methods for the Prediction, Validation and Characterization of Tumor Neo-antigens for Applications in Cancer Immunotherapy

Source : https://www.frontiersin.org/research-topics/9428/from-the-computer-to-the-clinic-methods-for-the-prediction-validation-and-characterization-of-tumor

Recognition and clearance of tumor cells by the immune system is now well established and forms the basis of cell-based therapies for treating cancer patients. Recent developments in cancer immunology .....

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Antibiotics reduce survival rates in cancer patients taking immunotherapy | Imperial News | Imperial College London

Antibiotics reduce survival rates in cancer patients taking immunotherapy | Imperial News | Imperial College London

Source : https://www.imperial.ac.uk/news/192887/antibiotics-reduce-survival-rates-cancer-patients/

Cancer patients on immunotherapy fare worse if they have recently taken antibiotics, with their response and overall survival rate 'crashing'. The findings come from a study of almost 200 cancer .....

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Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy

Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0732-8

Antibody-drug conjugates (ADCs) targeting the RON receptor, a tumorigenic factor contributing to cancer malignancy, has been considered as a novel strategy for cancer therapy. Here we describe a humanized antibody .....

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Tumors vs. Chronic Wounds: An Immune Cell's Perspective

Tumors vs. Chronic Wounds: An Immune Cell's Perspective

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02178/full

The wound repair program is tightly regulated and coordinated among different cell constituents including epithelial cells, fibroblasts, immune cells and endothelial cells following consecutive steps to ensure timely, and proper .....

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Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy

Influence of low-dose radiation on abscopal responses in patients receiving high-dose radiation and immunotherapy

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0718-6

Preclinical evidence suggests that low-dose radiation may overcome the inhibitory effects of the tumor stroma and improve a tumor's response to immunotherapy, when combined with high-dose radiation to another tumor. .....

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Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Source : https://clincancerres.aacrjournals.org/content/25/17/5260

Purpose: Clinically aggressive meningiomas (MGMs) are rare but treatment-resistant tumors in need for more effective therapies. Because tumor-infiltrating T lymphocytes (TILs) are essential for successful immunotherapy, we assessed TIL numbers .....

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Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma

Expression of CD38 on Macrophages Predicts Improved Prognosis in Hepatocellular Carcinoma

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02093/full

Background: CD38 is involved in the adenosine pathway, which represents one of the immunosuppressive mechanisms in cancer. CD38 is broadly expressed across immune cell subsets, including human macrophages differentiated in .....

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A 67-year-old female presents with chills and fever. She expresses fear that she may have the flu and is concerned about missing her next cancer treatment if she is sick. .....

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Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas

Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas

Source : https://clincancerres.aacrjournals.org/content/25/17/5271

Purpose: Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been implicated in the pathogenesis of germinal center (GC)-derived .....

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Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis

Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02120/full

Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment .....

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A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function

A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0721-y

Tumors can employ different mechanisms to evade immune surveillance and function. Overexpression of co-inhibitory ligands that bind to checkpoint molecules on the surface of T-cells can greatly impair the function .....

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Prognostic Significance of Potential Immune Checkpoint Member HHLA2 in Human Tumors: A Comprehensive Analysis

Prognostic Significance of Potential Immune Checkpoint Member HHLA2 in Human Tumors: A Comprehensive Analysis

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.01573/full

Immunological checkpoint inhibitors have been immensely successfully applied in the treatment of cancer, however, a portion of tumor patients can't benefit from checkpoint therapy. The low PD-1/CTLA-4 positive rate and .....

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Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer

Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer

Source : https://clincancerres.aacrjournals.org/content/25/17/5315

Purpose: Intratumoral hypoxia and immunity have been correlated with patient outcome in various tumor settings. However, these factors are not currently considered for treatment selection in head and neck cancer .....

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Oncology Center of Excellence will collaborate with the health data company to explore RWE sources for precision medicine. Note: additional articles are mentioned, to which you have free .....

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The Phase III NEPTUNE lung cancer trial found the combination of Imfinzi and tremelimumab was no better than chemotherapy at extending overall survival. After repeat setbacks, AstraZeneca is now running .....

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Cysteine Cathepsins in Tumor-Associated Immune Cells

Cysteine Cathepsins in Tumor-Associated Immune Cells

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02037/full

Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity and subcellular localization are associated with the distinct development and differentiation stages .....

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Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer

Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.01942/full

Ductal carcinoma in situ is a non-obligate precursor of breast cancer, and it only progresses to invasive breast cancer in around 40% of patients. While immune infiltrates have been observed .....

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Structure Based Prediction of Neoantigen Immunogenicity

Structure Based Prediction of Neoantigen Immunogenicity

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.02047/full

The development of immunological therapies that incorporate peptide antigens presented to T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated neoantigens are being explored .....

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Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200

Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0710-1

Samalizumab is a novel recombinant humanized monoclonal antibody that targets CD200, an immunoregulatory cell surface member of the immunoglobulin superfamily that dampens excessive immune responses and maintains self-tolerance. This first-in-human .....

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A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma

A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0703-0

Programmed cell death protein 1 (PD-1) is a key immune checkpoint that regulates peripheral tolerance and protects against autoimmunity. Programmed death ligand-2 (PD-L2) is a less studied ligand to PD-1 .....

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Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells

Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0676-z

Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that play an important role in immune evasion, PD-1/PD-L1 inhibitor tolerance and tumour progression. Therefore, MDSCs are potential targets for cancer immunotherapy. In .....

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Identification of a Promiscuous Epitope Peptide Derived... : Journal of Immunotherapy

Identification of a Promiscuous Epitope Peptide Derived... : Journal of Immunotherapy

Source : https://journals.lww.com/immunotherapy-journal/Fulltext/2019/09000/Identification_of_a_Promiscuous_Epitope_Peptide.2.aspx

tudy is to identify a promiscuous epitope peptide derived from HSP70 for the purpose of developing a novel cancer peptide vaccine. Using a computational algorithm to analyze the specificity of .....

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Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo

Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1649971

ABSTRACT Epithelial ovarian cancer (EOC) represents 5% of human gynecologic cancers in the world, is heterogeneous and highly invasive with a dismal prognosis (5 year-survival rate 95% of the ovarian .....

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Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Source : https://www.nature.com/articles/s41467-019-11719-3

Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood-brain barrier (BBB). .....

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Cancer Immunity and Immunotherapy

Cancer Immunity and Immunotherapy

Source : https://www.frontiersin.org/journals/immunology/sections/cancer-immunity-and-immunotherapy

Dramatic progresses have been made in the field of cancer immunity and immunotherapy during the preceding 15 years. The clinical impact associated with the tumor immune infiltrate, the impressive clinical .....

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NK Cell Dysfunction and Checkpoint Immunotherapy

NK Cell Dysfunction and Checkpoint Immunotherapy

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.01999

NK cells play important roles in the innate immune responses against tumors. The effector function of NK cells relies on the integration of activating and inhibitory signals. Emerging checkpoint receptors .....

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Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies

Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0665-2

The safety, efficacy, pharmacokinetics, and pharmacodynamics of the anti-programmed cell death-1 antibody MEDI0680 were evaluated in a phase I, multicenter, dose-escalation study in advanced solid malignancies. MEDI0680 was administered intravenously .....

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Sensitization of Tumors for Attack by Virus-Specific CD8 T-Cells Through Antibody-Mediated Delivery of Immunogenic T-Cell Epitopes

Source : https://www.frontiersin.org/journals/immunology/sections/cancer-immunity-and-immunotherapy

Dramatic progresses have been made in the field of cancer immunity and immunotherapy during the preceding 15 years. The clinical impact associated with the tumor immune infiltrate, the impressive clinical .....

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Clinical impact of T cells, B cells and the PD-1/PD-L1 pathway in muscle invasive bladder cancer: a comparative study of transurethral resection and cystectomy specimens

Clinical impact of T cells, B cells and the PD-1/PD-L1 pathway in muscle invasive bladder cancer: a comparative study of transurethral resection and cystectomy specimens

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1644108

(2019). Clinical impact of T cells, B cells and the PD-1/PD-L1 pathway in muscle invasive bladder cancer: a comparative study of transurethral resection and cystectomy specimens. OncoImmunology. Ahead of Print.

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Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1655360

ABSTRACTGlioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subg...

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Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1648170

ABSTRACTNon-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approache...

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Immunological Regulation of Vascular Inflammation During Cancer Metastasis

Immunological Regulation of Vascular Inflammation During Cancer Metastasis

Source : https://www.frontiersin.org/journals/immunology/sections/cancer-immunity-and-immunotherapy

Dramatic progresses have been made in the field of cancer immunity and immunotherapy during the preceding 15 years. The clinical impact associated with the tumor immune infiltrate, the impressive clinical .....

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Indocyanine green and poly I:C containing thermo-responsive liposomes used in immune-photothermal therapy prevent cancer growth and metastasis

Indocyanine green and poly I:C containing thermo-responsive liposomes used in immune-photothermal therapy prevent cancer growth and metastasis

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0702-1

Efficient cancer therapy is sought not only for primary tumor treatment but also for the prevention of metastatic cancer growth. Immunotherapy has been shown to prevent cancer metastasis by inducing .....

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Delivery of Antigen to CD8  Dendritic Cells by Fusing Antigen With Formyl Peptide Receptor-Like 1 Inhibitor Protein Induces Antitumor Immunity

Delivery of Antigen to CD8 Dendritic Cells by Fusing Antigen With Formyl Peptide Receptor-Like 1 Inhibitor Protein Induces Antitumor Immunity

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.01839

A major challenge for vaccine development is targeting antigens to dendritic cells (DCs) in vivo, enabling cross-presentation, and inducing the memory responses. Fcγ receptors (FcγRs) are expressed on many cell .....

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Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1648170

ABSTRACTNon-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approache...

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Cancer Immunity and Immunotherapy

Source : https://www.frontiersin.org/journals/immunology/sections/cancer-immunity-and-immunotherapy

Dramatic progresses have been made in the field of cancer immunity and immunotherapy during the preceding 15 years. The clinical impact associated with the tumor immune infiltrate, the impressive clinical .....

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The Obesity Paradox in Cancer, Tumor Immunology, and Immunotherapy: Potential Therapeutic Implications in Triple Negative Breast Cancer

The Obesity Paradox in Cancer, Tumor Immunology, and Immunotherapy: Potential Therapeutic Implications in Triple Negative Breast Cancer

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.01940

Cancer immunotherapy has been heralded as a breakthrough cancer treatment demonstrating tremendous success in improving tumor responses and survival of patients with hematological cancers and solid tumors. This novel promising .....

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Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Source : https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0704-z

Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition (iRT) .....

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The TNF Paradox in Cancer Progression and Immunotherapy

The TNF Paradox in Cancer Progression and Immunotherapy

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2019.01818

Tumour necrosis factor alpha (TNF)-dependent modulation of immune responses and cell death processes has long been the subject of intense research. Yet, its role in cancer progression is still a .....

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